Contribution of the Receptor/Ligand Interaction Between CD44 and Osteopontin to Formation of Breast Cancer Metastases

Abstract

Splice variants of the homing receptor CD44 may mediate metastasis formation by various tumors through interaction with the cytokine osteopontin which mediates cell attachment or migration. We have identified the mechanism of cell motility as a two-step process involving both major osteopontin receptors. We have further characterized the important involvement of osteopontin in delayed type immune responses which may have implications for tumor immunology. Future experiments will define CD44-dependent homing and invasion in vivo using our recently generated stably transfected tumor cells of various CD44 splice variants.

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Document Details

Document Type
Technical Report
Publication Date
Jul 01, 1999
Accession Number
ADA384133

Entities

People

  • George F. Weber

Organizations

  • Dana–Farber Cancer Institute

Tags

DTIC Thesaurus Topics

  • Amino Acids
  • Cell Line
  • Cell Movement
  • Cell Physiological Processes
  • Cells
  • Cellular Structures
  • Chemistry
  • Cytoskeleton
  • Genetics
  • Health Services
  • Lymphocytes
  • Macrophages

Fields of Study

  • Biology
  • Medicine

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