Drug Discovery and Structural Bioinformatics in Breast Cancer
Abstract
The purpose of this Sabbatical Training Grant from the USAMRMC Breast Cancer Program was to provide the training, dedicated time, and computational resources necessary for the development of a research program on Drug Discovery and Structural Bioinformatics in Breast Cancer. The development of innovative therapeutic and/or chemopreventive approaches for breast cancer will involve the identification of novel macromolecular targets, the discovery of novel lead drug candidates, and drug design and development. The biological focus of our research addresses estrogen biosynthesis and on estrogen- induced gene expression in hormone-dependent breast cancer. Identification of critical small molecule-protein and protein-protein interactions during gene expression and signal transduction in the areas of steroidogenesis and estrogen-induced responses will result in new molecular targets for drug discovery and design for the treatment of hormone-dependent breast cancer. The Sabbatical Training Grant provided an enhancement of our research endeavors by utilizing computational and experimental tools for macromolecular target identification, target validation, and lead identification. The objectives of the funded grant were accomplished: (1) obtained the computational resources (hardware, software) for database searching, computational analysis, structure prediction, and homology-based structure modeling; (2) developed expertise in peptide and protein model building, homology-based protein construction, 3-D conformational analysis, and receptor pharmacophore modeling through intensive research-based workshops, on-site training, and extended visits to national laboratories; (3) applied these structural bioinformatics approaches to the analysis of gene and protein sequences involved in macromolecular interactions in breast cancer; and (4) initiated medicinal chemistry and biochemistry research using subcellular and cell culture studies.
Document Details
- Document Type
- Technical Report
- Publication Date
- Dec 01, 1999
- Accession Number
- ADA384146
Entities
People
- Robert W. Brueggemeier
Organizations
- Ohio State University