Mammalian Homologs of Yeast Checkpoint Genes

Abstract

We hypothesize that components of DNA-related checkpoint pathways in addition to members of the ATM protein/lipid kinase family are conserved in all eukaryotes. This is based on functional similarities in the pathways and the conservation between the evolutionarily disparate budding and fission yeasts. Our goal is to identify additional regulators of mammalian DNA checkpoints, by virtue of structural and functional homology with known checkpoint genes in budding yeast. We will use both structural and functional screens to identify human homologs of yeast damage checkpoint proteins Rad53 and Rad9. Once identified, such components will be ordered into pathways for mammalian checkpoint function, with emphasis on p53 regulation, cell cycle regulation, and complementation of ATM defects.

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Document Details

Document Type
Technical Report
Publication Date
Jul 01, 1999
Accession Number
ADA384149

Entities

People

  • David F. Stern

Organizations

  • Yale University

Tags

DTIC Thesaurus Topics

  • Amino Acids
  • Animals
  • Biomedical Research
  • Breast Cancer
  • Cell Physiological Processes
  • Cells
  • Chemistry
  • Eukaryotes
  • Fungi
  • Genetic Structures
  • Identification
  • Ionizing Radiation
  • Laboratory Animals
  • Materials
  • Peptides
  • Recombinant Dna
  • Regulations

Fields of Study

  • Biology

Readers

  • Molecular Genetics