Role of the Spindle Checkpoint in Preventing Breast Cancers

Abstract

Abnormal chromosome number is a phenotype characteristic for most of the cancer cells. Thus, it may be a direct cause of human cancer including breast cancer. In this research project, we aim to test this hypothesis by abrogating the spindle checkpoint that is a major surveillance mechanism responsible for maintenance of the normal chromosome number. p55CDC serves as a target of the checkpoint. If it is unable to bind to a spindle checkpoint protein, Mad2, it abrogates the checkpoint in a dominant manner. In Year 1 of this project, we have carried out a large scale mutagenesis to generate mutants of p55CDC that are defective in binding to Mad2.

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Document Details

Document Type
Technical Report
Publication Date
Jul 01, 2000
Accession Number
ADA384154

Entities

People

  • Tomohiro Matsumoto
  • Toshiyuki Habu

Organizations

  • Albert Einstein College of Medicine

Tags

DTIC Thesaurus Topics

  • Anatomy
  • Biomedical Research
  • Breast Cancer
  • Cell Line
  • Cells
  • Chromosomes
  • Cultured Cells
  • Fungi
  • Genetic Phenomena
  • Genetic Structures
  • Genetics
  • Hot Spots
  • Laboratory Animals
  • Materials
  • Neoplasms
  • New York
  • Recombinant Dna

Fields of Study

  • Biology
  • Medicine

Readers

  • Molecular and Cellular Biology
  • Molecular and genetic basis of cancer.
  • Oncology (Cancer Research).