Examination of the Role of Membrane Type-1 Matrix Metalloproteinase (MTI-MMP) in Breast Cancer Metastasis

Abstract

MT-MMPs are able to activate progelatinase A on the surface of tumor cells by producing an initial cleavage in the N-terminal propeptide domain followed by an autolytic cleavage. Because of its central role in cell surface proteolysis, a more complete understanding of the role of MT-MMPs in cancer will expedite progress in therapy of metastasis. To this end, this project has been focused on the role of MT1-MMP in experimental breast cancer invasion and metastasis.

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Document Details

Document Type
Technical Report
Publication Date
Aug 01, 1999
Accession Number
ADA384239

Entities

People

  • Jian Cao
  • Stanley Zucker

Organizations

  • State University of New York

Tags

DTIC Thesaurus Topics

  • Animals
  • Biomedical Research
  • Breast Cancer
  • Cancer
  • Cell Line
  • Cell Membrane
  • Cells
  • Cellular Structures
  • Golgi Apparatus
  • Laboratory Animals
  • Materials
  • Membranes
  • Metastasis
  • Molecules
  • Neoplasms
  • New York
  • Recombinant Dna

Fields of Study

  • Biology
  • Chemistry

Readers

  • Molecular Biology and Genetics