Characterization of the Molecular Basis of Cell Recognition at Surfaces
Abstract
Molecular recognition interactions have been studied via atomic force microscopy using specially modified tips. Tip-surface interaction forces in the piconewton range were measured. From the from force-tip separation relationships significant information has been obtained about molecular scale interactions. In particular, analysis of mixed phospholipid/glycolipid bilayers has resulted in a clear understanding of the different forces involved. This work leads to a better understanding of molecular recognition events involving cell adhesion and complex biological reactions, such as healing, and has potential use in ultra sensitive biosensors.
Document Details
- Document Type
- Technical Report
- Publication Date
- Dec 31, 1998
- Accession Number
- ADA384249
Entities
People
- David L. Allara
Organizations
- Pennsylvania State University