Acute Inhalation Toxicity of Chemically Neutralized HD in Rats
Abstract
The chemical agent HD (sulfur mustard) was neutralized by hot water (90 C) hydrolysis to produce a markedly less toxic wastestream (product solution). An acute inhalation toxicity test was conducted on the HI) neutralized solution to assess the inhalation hazard per Department of Transportation (DOT) guidelines. Sprague-Dawley rats were exposed for 1 hr to an aerosol concentration of 5.4 mg/L, which consisted primarily of the HD hydrolysis solution of thiodiglycol and water. No overt signs of toxicity attributed to HD were manifested in the animals. The rats did not exhibit any other signs of either irritation or overt toxicity during either the exposure or post%exposure periods. No deaths occurred within the 14-day post-exposure period. The product solution from the hot water hydrolysis (neutralization) of HD does not appear to pose an acute inhalation hazard.
Document Details
- Document Type
- Technical Report
- Publication Date
- Sep 01, 2000
- Accession Number
- ADA384252
Entities
People
- Charles L. Crouse
- J. S. Anthony
- Lee C. Crouse
- Sandra A. Thomson
- William T. Muse Jr.