Neuroprotective Treatment of Laser-Induced Retinal Injuries
Abstract
Laser induced retinal injuries are operational and medical problem in the battlefield as a result of lasers used in military equipment and the introduction of visually incapacitating laser weapons. It is not possible to prevent all these injuries and there is no treatment. This study was designed to evaluate the neuroprotective effect of memantine in our rat model of laser-induced retinal-lesions. Methods: Argon laser retinal lesions were inflicted in the eyes of 36 pigmented rats. The treated group received memantine 10 mg/kg dissolved in saline, immediately after exposure to laser and then every S hours for 3 days. The control group received the solvent at the same volume and schedule. The rats were sacrificed 3, 20 or 60 days later and the retinal lesions were evaluated by light microscopy and morphometric measurements.
Document Details
- Document Type
- Technical Report
- Publication Date
- Oct 01, 2000
- Accession Number
- ADA384348
Entities
People
- Michael Belkin
- Mordechai Rosner
- Yoram Solberg
Organizations
- Tel Aviv University