Design and Synthesis of New Prostate Cancer Chemotherapeutic Agents
Abstract
This proposal is directed towards the development of new chemotheareapeutic agents based on the mechanism of action of Taxol. The recent discovery of two other natural products, epothilone and eleutherobin, that operate by the same unique mechanism of action as Taxol, i.e., microtubule stabilization, provides a unique opportunity for a collaborative approach using synthetic and computational studies for the elucidation of the pharmacophore common to these structurally dissimilar substances. Such an advance could lead to the development of a novel family of prostate cancer chemotherapeutics. We describe herein our approach to the synthesis of novel analogs of the potent antitumor agent eleutherobin.
Document Details
- Document Type
- Technical Report
- Publication Date
- Sep 01, 1999
- Accession Number
- ADA384353
Entities
People
- Jeffrey D. Winkler
Organizations
- University of Pennsylvania