Comparison of Novel and Known Neuroprotectants for Treating Exposure to Different Types of Toxins
Abstract
Hippocampal slice cultures were used to examine excitotoxic responses to AMPA and the neurotoxin trimethyltin (TMT) known to cause seizures and hippocampal damage. Relatively short exposure to AMPA and extensive infusion of TMT caused spectrin fragmentation and synaptic deterioration that persisted after a 24-h recovery period. Several avenues of protection were effective at promoting recovery when initiated post-insult. These include anti-inflammatory agents, an anticonvulsant, and modulators of AMPA receptors (Ampakines) that enhance excitatory communication.
Document Details
- Document Type
- Technical Report
- Publication Date
- Sep 01, 2000
- Accession Number
- ADA384358
Entities
People
- Ben A Bahr
Organizations
- University of Connecticut