Triterpenoids and Prevention of Prostate Cancer
Abstract
This entire project is based on the hypothesis that we can design and develop new synthetic triterpenoids that would eventually be useful for chemoprevention of prostate cancer. With the known importance of oxidative stress and the known involvement of the enzymes, inducible cyclooxygenase (COX-2) and inducible nitric oxide synthase (iNOS), in the process of carcinogenesis in several other organs, and our own preliminary findings that new synthetic triterpenoids can block de novo induction and synthesis of both these enzymes, there is now a sound mechanistic basis for this hypothesis. Furthermore, since we have already shown that new synthetic triterpenoids can inhibit cell growth, without evident cytotoxicity, in non-malignant prostate epithelial cells, we believe that it will be possible to design and synthesize even more effective triterpenoids for this purpose. Finally, it is critical that a receptor (or receptors) for triterpenoids be defined, since these are presently unknown.
Document Details
- Document Type
- Technical Report
- Publication Date
- Oct 01, 1999
- Accession Number
- ADA384364
Entities
People
- Michael B. Sporn
Organizations
- Dartmouth College