Wnt-1 Signaling in Mammary Carcinogenesis
Abstract
WNT GENES ENCODE A LARGE FAMILY OF SECRETED SIGNALING MOLECULES ESSENTIAL FOR DEVELOPMENT AND ONCOGENESIS. WNT-1, THE FOUNDING MEMBER OF THE WNT GENE FAMILY, WAS INITIALLY IDENTIFIED AS AN ONCOGENE. Ectopic wnt-1 expression causes mammary tumorigenesis in mice, providing a potential model for human breast cancer. However, the cell surface receptor (or receptors) that mediates Wnt-1 signaling has not been identified, and the molecular and biochemical nature of the Wnt signaling pathway is not fully understood. In a research supported in part by this Career Development Award, I propose experiments combining molecular techniques and the axis duplication assay in the Xenopus embryo to answer two critical questions: 1) What is the receptor mediating Wnt-1 oncogenic function? 2) How does the Dishevelled protein, which is an essential Wnt signaling component, transduce Wnt-1 signal? Here I provide a progress report on our studies on a potential receptor function of LRP6, a member of the LDL receptor-related protein family, in Wnt signal transduction.
Document Details
- Document Type
- Technical Report
- Publication Date
- Apr 01, 2000
- Accession Number
- ADA384378
Entities
People
- Xi He