New Method for Breast Cancer Diagnosis

Abstract

Our aim was to develop a new method for breast cancer diagnosis by measuring prostate specific antigen subfractions in serum. Prostate specific antigen (PSA) is a serine protease expressed at high levels in prostate epithelium and elevated PSA in serum is a well-established marker of prostate cancer. Recently, the relative proportions of free PSA and PSA complexed to the serine protease inhibitor alpha-1-antichymotrypsin (PSA-ACT) have become important variables in distinguishing between prostate cancer and benign pro static hyperplasia. Numerous studies have demonstrated the production of PSA in female tissues such as the breast, and low levels of PSA are present in female sera. The objective of this study was to measure and compare the relative proportions of free PSA and PSA-ACT in the serum of women with breast cancer, benign breast disease, or women with no known malignancies.

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Document Details

Document Type
Technical Report
Publication Date
Sep 01, 1999
Accession Number
ADA384500

Entities

People

  • Eleftherios P. Diamandis

Organizations

  • Mount Sinai Hospital, Toronto

Tags

DTIC Thesaurus Topics

  • Albumins
  • Biomedical And Dental Materials
  • Biomedical Research
  • Breast Cancer
  • Cancer
  • Cells
  • Chemistry
  • Cysts
  • Detection
  • Diseases And Disorders
  • Health Services
  • Liquid Chromatography
  • Materials
  • Neoplasms
  • Oncology
  • Polymeric Films
  • Prostate Cancer

Fields of Study

  • Medicine

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