Isolation of Genes From Chromosome Region Ip31 Involved in the Development of Breast Cancer

Abstract

Loss of heterozygosity (LOH) involving the p31 region of chromosome 1 has been reported as one of the most frequent genetic changes in human breast cancer. LOH is generally considered a mechanism for exposing recessive mutations in genes critical for tumorigenesis. We have begun creating a contiguous array of bacterial artificial chromosome (BAC) clones spanning the minimum region in Ip31 defined by LOH studies. These clones will facilitate the search for genes from the region which can be tested for mutations in breast tumors. One such gene, TTC4, has been identified, cloned and characterized. This gene contains a tetratricopeptide repeat motif which has been implicated in protein-protein binding and one member of this extended family of genes has been implicated in liver tumorigenesis.

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Document Details

Document Type
Technical Report
Publication Date
Sep 01, 1999
Accession Number
ADA384614

Entities

People

  • John K. Cowell

Tags

DTIC Thesaurus Topics

  • Amino Acids
  • Breast Cancer
  • Cell Line
  • Cells
  • Chromosomes
  • Families (Human)
  • Fungi
  • Genes
  • Genetic Code
  • Genetic Phenomena
  • Genetic Structures
  • Genetics
  • Materials
  • Mutations
  • Neoplasms
  • Polymerase Chain Reaction

Fields of Study

  • Biology

Readers

  • Molecular Genetics
  • Molecular and genetic basis of cancer.

Technology Areas

  • Biotechnology