Neurobehavioral and Immunological Toxicity of Pyridostigmine, Permethrin and DEET in Males and Females
Abstract
These experiments were conducted to investigate to what extent relatively small doses of pyridostigmine bromide (PB), permethrin (Perm) and N,N, diethyl-m-toluamide (DEET) alone, or in different combinations affect neurobehavioral and immunological outcome in male and female rats. Small doses of PB produced neurobehavioral consequences that sometimes differed between male and female rats (decrease in locomotor activity, impairment in learning and performance). Perm and DEET administration alone did not greatly affect locomotor activity (and learning in the case of Perm). PB, Perm and DEET dose-dependently decreased schedule performance. Some synergistic effects were observed in male rats when Perm and DEET were co-administered with PB. PB administration resulted in higher serum PB levels in pro-estrus females than in met-estrus females and intact males. PB administration changed Perm serum levels as they were much higher when Perm was co-administered with PB. Perm levels were higher in female rats than in male rats. These behavioral and neurochemical effects were observed in rats that were free of stress other than that inflicted by participation in the research protocol.
Document Details
- Document Type
- Technical Report
- Publication Date
- May 01, 2000
- Accession Number
- ADA384683
Entities
People
- Frans V. Haaren
Organizations
- University of Florida