DNA Damage, Fruits and Vegetables and Breast Cancer Prevention
Abstract
The purpose of this project is to evaluate the effect(s) of increasing fruit and vegetable intake on oxidative DNA damage and lipid peroxidation in a population of women at elevated risk for breast cancer. The rationale that underlies the work proposed is based on evidence that the occurrence of DNA mutations are essential steps in carcinogenesis and that these mutagenic events can result from oxidative stress, even in the absence of exogenous carcinogens. The effects of consuming a recipe-defined diet designed to provide three (control) or ten (intervention) servings of fruits and vegetables per day for a period of 8 weeks on measures of oxidative damage to DNA and lipids is being determined. During this reporting period, we have expanded the initial two-week dietary intervention so that subjects can follow the dietary prescription for 8 weeks. Based on study results, key variables that required modification were related to convenience of meal preparation and flexibility in the selection of alternative foods from within the same botanical family. Barriers research identified alienation from family members due to eating a different diet, limitations in eating meals out of home, and lack of favorite food items as significant obstacles to maintaining dietary compliance.
Document Details
- Document Type
- Technical Report
- Publication Date
- Aug 01, 2000
- Accession Number
- ADA384801
Entities
People
- Henry Thompson