Gene Therapy in a Nonhuman Primate Model of Parkinson's Disease

Abstract

This grant is studying the ability to deliver the trophic factor glial derived neurotrophic factor (GDNF) via in vivo and ex vivo viral vectors In nonhuman primates. In this second year, critical studies have been performed and completed. In the first experiment, lentiviral delivery of GDNF was attempted in aged nonhuman primates. These injections resulted in a dramatic increase in dopaminergic markers in this model of early Parkinson's disease.

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Document Details

Document Type
Technical Report
Publication Date
Oct 01, 2000
Accession Number
ADA384809

Entities

People

  • Jeffrey H. Kordower

Organizations

  • Rush University Medical Center

Tags

DTIC Thesaurus Topics

  • Arteries
  • Brain
  • Cells
  • Central Nervous System
  • Diseases And Disorders
  • Gene Delivery
  • Gene Therapy
  • Genetics
  • Lymphocytes
  • Movement Disorders
  • Nervous System
  • Neuroglia
  • Neurons
  • Neurosciences
  • Parkinson'S Disease
  • Surgery
  • Therapy

Fields of Study

  • Biology
  • Medicine

Readers

  • Molecular Genetics
  • Neuroscience

Technology Areas

  • Biotechnology