Efficacy of Biperiden and Atropine as Anticonvulsant Treatment for Organophosphorus Nerve Agent Intoxication

Abstract

The ability of the nerve agents tabun, sarin, soman, GF, VR, and VX to produce brain seizures and the effectiveness of the anticholinergics biperiden HCl or atropine SO4 as an anticonvulsant treatment were studied in a guinea-pig model. The present study demonstrates that all nerve agents can produce status epilepticus and that the therapeutic effectiveness of atropine and biperiden roughly paralleled the seizurogenic potential of these agents.

Open PDF

Document Details

Document Type
Technical Report
Publication Date
Jan 01, 2000
Accession Number
ADA385192

Entities

People

  • John H. McDonough
  • T.-m. Shih

Organizations

  • United States Army Medical Research Institute of Chemical Defense

Tags

DTIC Thesaurus Topics

  • Alcohols
  • Anticonvulsants
  • Atropine
  • Biomedical Research
  • Brain Injuries
  • Central Nervous System
  • Chemical Warfare
  • Confidence Limits
  • Epilepsy
  • Intoxication
  • Laboratory Animals
  • Medical Personnel
  • Nerve Agents
  • Organophosphorus Compounds
  • Rodents
  • Seizures
  • Therapy

Fields of Study

  • Medicine

Readers

  • Neurotoxicology