Histopathologic Changes in the Brain, Heart, and Skeletal Muscle of Rhesus Macaques, Ten Days After Exposure to Soman (An Organophosphorus Nerve Agent)

Abstract

Soman, an organophosphorus, anticholinergic, chemical warfare nerve agent, is studied at few research facilities, and there have been few pathologic studies of soman-exposed primates. We describe the brain, heart, and skeletal muscle lesions, review lesions described in literature, and discuss possible pharmacologic mechanisms for soman-induced neuron necrosis.

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Document Details

Document Type
Technical Report
Publication Date
Apr 01, 2000
Accession Number
ADA385193

Entities

People

  • Carlin V. Okerberg
  • Edward J. Dick Jr.
  • James O. Britt
  • Jamie L. Martin

Organizations

  • United States Army Medical Research Institute of Chemical Defense

Tags

DTIC Thesaurus Topics

  • Anticonvulsants
  • Brain
  • Cells
  • Health Services
  • Laboratory Animals
  • Medical Personnel
  • Nerve Agents
  • Neurons
  • Peripheral Nervous System
  • Rodents
  • Skeletal Muscle

Fields of Study

  • Medicine

Readers

  • Cardiovascular Physiology
  • Neuroscience
  • Neurotoxicology