The Effects of WR242511 in Rhesus Monkeys
Abstract
Many substances that form methemoglobin (MHb) counter cyanide (CN) toxicity. Although MHb formers can be applied as treatments for CN poisoning, it was reasoned that a long-acting MHb former could serve as a CN pretreatment. An 8- aminoquinoline drug, WR242511, was characterized as a long-lasting MHb former, producing sufficient MHb to protect against 2 X LD50 of CN. Transition for development of WR242511 was based on data from rodents and beagle dogs collected elsewhere. Advanced development testing of WR242511 at USAMRICD was conducted in the rhesus monkey. WR242511 was administered intravenously (IV) to two female and four male rhesus monkeys in doses of 3.5 and/or 7.0 mg/kg, with the objective of producing protective levels of MHb.
Document Details
- Document Type
- Technical Report
- Publication Date
- May 01, 2000
- Accession Number
- ADA385196
Entities
People
- Crystal M. Briscoe
- Gary A. Rockwood
- Kevin R. Armstrong
- Mark B. Gold
- Steven M. Duniho
Organizations
- United States Army Medical Research Institute of Chemical Defense