Membrane-Bound Hyaluronidase in Breast Cancer Progression

Abstract

Malignant breast cancer cells express high level of hyaluronidase (HAase). However, the pathological function of the elevated HAase is unclear. To determine the role of HAase in the progression of tumor, we first test the effect of exogenous HAase on colony formation of cancer cells. When bovine testicular HAase (membrane-bound HAase) was added to MDA 468 cells, the colony formed in soft agar was greatly stimulated. The underlying mechanism study suggested that HAase could act as a switch for release of growth factor that immobilized in extracellular matrix. The ELISA data indicated that this release was FGF-2 specific, not VEGF.

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Document Details

Document Type
Technical Report
Publication Date
Sep 01, 1999
Accession Number
ADA385281

Entities

People

  • Lurong Zhang

Organizations

  • Georgetown University

Tags

DTIC Thesaurus Topics

  • Biological Factors
  • Breast Cancer
  • Cancer
  • Cell Line
  • Cell Physiological Processes
  • Cells
  • Chemistry
  • Culture Media
  • Epithelial Cells
  • Growth Factors
  • Health Services
  • Membranes
  • Neoplasms
  • Peptide Growth Factors
  • Peptides
  • Proteins
  • Tumor Cell Line

Fields of Study

  • Biology

Readers

  • Molecular and Cellular Biochemistry
  • Oncology (Cancer Research).