Biology of Somatostatin and Somatostatin Receptors in Breast Cancer

Abstract

Breast tumors show rich expression of multiple SSTR subtypes and may be amenable to treatment with selective SST compounds. All five SSTRs variably inhibit cell growth. When studied as individual subtypes expressed in host cells, SSTR3 is the only isoform that induces apoptosis whereas SSTR1,2,4 and 5 promote cell growth arrest with SSTR5 exerting the most potent effect. Both apoptotic and cytostatic signalling are dependent on receptor-mediated activation of SHP-1. Cytostasis then proceeds through activation of Rb and p21 whereas apoptosis is associated with caspase-8-mediated intracellular acidification and decrease in mitochondrial membrane potential.

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Document Details

Document Type
Technical Report
Publication Date
Sep 01, 2000
Accession Number
ADA385291

Entities

People

  • Yogesh C. Patel

Organizations

  • McGill University

Tags

Communities of Interest

  • Biomedical

DTIC Thesaurus Topics

  • Cell Physiological Processes
  • Cells
  • Chemical Synthesis
  • Chemistry
  • Endocrine Glands
  • Health Services
  • Medical Personnel

Fields of Study

  • Biology

Readers

  • Cellular and Molecular Pathways of Apoptosis.
  • Oncology (Cancer Research).