HER-2/neu Shedding and Oncogenesis
Abstract
The HER-2/neu extracellular domain (ECD) is shed from breast carcinoma cells in culture and is found at elevated levels in sera of patients with metastatic breast cancer where it may predict poor prognosis. Our studies show that an N-terminally truncated HER-2/neu product, p95, is produced when the ECD is shed, that p95 has kinase activity, and is expressed to a greater extent in breast cancer patients with lymph node metastasis. Purpose. The objective of this proposal is to directly test the hypothesis that shedding of the extracellular domain of HER-2/neu, which creates the truncated p95 kinase, promotes oncogenesis. Scope. The effect of shedding to oncogenesis will be examined by further characterizing the control of shedding and genetically altering shedding activity to test the impact on tumorigenesis and oncogenesis. Results:
Document Details
- Document Type
- Technical Report
- Publication Date
- Jul 01, 2000
- Accession Number
- ADA385292
Entities
People
- Gail M. Clinton
Organizations
- Oregon Health & Science University