Synthesis of Clustered ST-Antigens for the Development of Novel Breast Cancer Vaccines

Abstract

The development of efficient routes for the preparation of complex oligosaccharide or carbohydrate conjugates has been our immediate purpose. A more global goal would be that of recruiting the immune system to respond to malignant lesions. In our continuing chemical studies, we have undertaken to develop synthetic methodology of general applicability for the preparation of carbohydrates, in the form of glycolipids and glycopeptides, which mimic components of the accessible cell surface of tumor cells. The report herein focuses on successful syntheses of mucin related 0-linked glycopeptides, in particular the TF and 2,3-STF antigens. TF is observed on a variety of epithelial tumors and 2,3-STF is observed on a large number of breast tumors.

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Document Details

Document Type
Technical Report
Publication Date
Apr 01, 1999
Accession Number
ADA385369

Entities

People

  • Samuel Danishefsky
  • Scott D. Kuduk

Organizations

  • Memorial Sloan Kettering Cancer Center

Tags

DTIC Thesaurus Topics

  • Antigens
  • Biomedical And Dental Materials
  • Breast Cancer
  • Carbohydrates
  • Chemical Compounds
  • Chemical Synthesis
  • Chemistry
  • Glycoconjugates
  • Immune System
  • Neoplasms
  • Organic Chemistry
  • Vaccines

Fields of Study

  • Chemistry

Readers

  • Immunology
  • Nanocomposite Materials Science

Technology Areas

  • Biotechnology
  • Biotechnology - Cancer Biotech