Transcriptional Regulation of BRCA1

Abstract

The principal aim of my project was to characterize the transcriptional regulation of the breast cancer susceptibility gene, BRCAl. This purpose of the project has gained greater importance in light the following observations by several laboratories: (1) A significant number of higher grade breast cancers have decreased expression of BRCAl mRNA and proteins and (2) BRCAl transcriptional promoters have been reported to be methylated in some sporadic breast cancers as opposed to lack of metylation in normal breast tissues. These studies suggested that suppression of BRCAl transcription may contribute to the development of a subset of breast cancer. Therefore, the present studies may not only give greater insight into the functional pathways in which BRCAl participates in, but also provide clues regarding the pathogenesis of breast neoplasms.

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Document Details

Document Type
Technical Report
Publication Date
Aug 01, 1999
Accession Number
ADA385370

Entities

People

  • Carlo Croce
  • Sanjay Thakur

Organizations

  • Thomas Jefferson University

Tags

DTIC Thesaurus Topics

  • Breast Cancer
  • Cell Line
  • Cells
  • Chemical Reactions
  • Chemical Synthesis
  • Chemistry
  • Chromosomes
  • Competition
  • Genes
  • Genetics
  • Materials
  • Molecular Biology
  • Molecules
  • Neoplasms
  • Organic Chemistry
  • Regulations
  • Tumor Cell Line

Readers

  • Breast cancer cell signaling and growth regulation.
  • Molecular and genetic basis of cancer.