Cytochrome P450-17alpha Polymorphism and Risk of Breast Cancer
Abstract
The current study investigates whether polymorphisms in the CYP 17 gene, which plays roles in estrogen biosynthesis, are associated with an altered risk of breast cancer in a population-based sample of women (400 cases and 400 controls) who participated in the Long Island Breast Cancer Study Project (LIBSCP). In addition, we are also exploring whether the effects of reproductive risk factors and exposure to exogenous estrogen are modified by CYP 17 polymorphisms. In the past year, laboratory assays on CYP 17 polymorphisms are being conducted in the Division of Environmental Health Sciences of Columbia University. The polymorphisms are being determined by PCR-RFLP methods with a digestion by appropriate restriction enzymes. To date, assays on 300 cases and 300 controls have been performed. Delays in subject and sample selection in the parent LIBSCP study delayed Task 1, thus delaying the start of laboratory analyses. Therefore, Task 2 will not be completed until the end of September 1999. Entry of laboratory data to computers and merging of laboratory data with questionnaire data (Task 3) are estimated to begin in October 1999. Data analysis, manuscript preparation and report writing (Tasks 4 & 5) will take place in the coming year.
Document Details
- Document Type
- Technical Report
- Publication Date
- Aug 01, 1999
- Accession Number
- ADA385380
Entities
People
- Habibul Ahsan
Organizations
- Columbia University