99M Tc-Peptides for Detection of Breast Cancer
Abstract
The goal of this project is to select for a peptide, using phage display libraries, which recognizes an EGF mutant receptor present in tumor cells. Phage display is a methodology which offers great potential for cancer diagnostic agents. The peptide(s) selected will be radiolabeled with technetium-99m and tested in vitro and in in vivo mouse tumor models for their potential as agents for detection, through nuclear imaging, of breast cancers which expresses the mutant EGF receptor. If successful, this Tc4abeled mutant EGF-binding protein could serve not only as a useful agent in the diagnosis of breast cancer through imaging, but potentially be applicable to other cancers as well. Although not part of this proposal, the novel peptide selected as may be useful in therapy, by serving as a targeting agent in the delivery of therapeutic cancer drugs directly to cancer cells.
Document Details
- Document Type
- Technical Report
- Publication Date
- Aug 01, 2000
- Accession Number
- ADA385412
Entities
People
- Mary Rusokowski
Organizations
- University of Massachusetts Medical School