Mammary-Specific Gene Transfer for Modeling Breast Cancer
Abstract
Several genetic alterations have been identified in breast cancer, yet the molecular mechanisms leading to breast tumorigenesis are unknown. In order to develop a mouse model system that can dissect the genetic pathways involved in breast tumor development, we are adapting a somatic gene transfer system based on avian leukosis virus A (ALV-A) expression vectors and the TVA receptor for ALV-A. Transgenic mice have been generated that target tv-a to the mammary epithelial cells using MMTV and WAP promoters. Mammary epithelial cells from these transgenic mice are susceptible to infection both in vivo and in vitro. The animals developed should be valuable for gene delivery using the ALV-TVA vector system.
Document Details
- Document Type
- Technical Report
- Publication Date
- Aug 01, 2000
- Accession Number
- ADA385414
Entities
People
- Harold E. Varmus
Organizations
- National Institutes of Health