Cloning of Novel Oncogenes Involved in Human Breast Cancer
Abstract
During the past year, we initiated our own efforts to utilize cDNA expression libraries in retrovirus vectors to screen for novel oncogenes. We have collected 8 breast cancer samples, representing either localized, noninvasive tumor tissue from invasive cancers. The rationale for choosing the noninvasive samples was that this screen would involve the identification of oncogenes involved in tumor progression, and hence, may serve as important diagnostic markers for early detection. The rationale for using the invasive tumor tissue is that these cancer cells are likely to harbor more genetic defects that noninvasive tumor cells and consequently, our chances of detection are increased. A second rationale for studying late stage cancers is that oncogenes involved promoting invasion and metastases may be identified. The identification of such genes are obviously important as both diagnostic markers for metastases and as targets for drug discovery.
Document Details
- Document Type
- Technical Report
- Publication Date
- Jun 01, 2000
- Accession Number
- ADA385419
Entities
People
- Channing Der
Organizations
- University of North Carolina at Chapel Hill