Gene Delivery for Metastatic Prostate Cancer Cells

Abstract

We have developed a prostate-specific vector to deliver the diphtheria toxin A gene into cancer cells. Using liposome-mediate DNA transfection, the vector specifically destroys prostate cancer cells. Enhanced by the by-stander effect, the specific expression of the diphtheria toxin A gene causes significant cell death in prostate cancer cell culture, with very low background in the control cell lines. The highly specific and efficient cytopathicity combined with low immunogenicity of the diphtheria toxin A gene vector will potentially be useful for systemic treatment of patients with metastatic prostate cancer.

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Document Details

Document Type
Technical Report
Publication Date
Jan 01, 2000
Accession Number
ADA385423

Entities

People

  • Shen Pang

Organizations

  • University of California, Los Angeles

Tags

DTIC Thesaurus Topics

  • Actinomycetales Infections
  • Cell Line
  • Cell Physiological Processes
  • Cells
  • Culture Techniques
  • Cultured Cells
  • Gene Delivery
  • Gene Expression
  • Gene Therapy
  • Materials
  • Neoplasms
  • Polymerase Chain Reaction
  • Prostate
  • Prostate Cancer
  • Synthetic Membranes
  • Tissues
  • Tumor Cell Line

Fields of Study

  • Biology
  • Medicine

Readers

  • Immunology
  • Molecular Biology and Genetics
  • Oncology