HRAD51 Involvement in Genomic Instability and Development of Breast Cancer
Abstract
It becomes increasingly clear that both BRCA1 and BRCA2 tumor suppressor genes are involved in hRAD51-dependent DNA repair by homologous recombination. In this study, we will test whether DNA recombinational repair may be compromised during breast cancer development. We first examined the hRAD51 gene in tumors with 15q14-15 deletions. We did not find any changes compared to normal tissue which supports (among other possibilities, see accompanying reprint) the notion that hRAD51 is an essential gene. We have also examined interactions among members of the hRAD51 protein family and between hRAD51 family members and BRCA1/2. All hRAD51 homologs seem to exist in a multiprotein complex (hRAD51 proteome), and examination of the functional significance of these interactions is currently in progress.
Document Details
- Document Type
- Technical Report
- Publication Date
- Sep 01, 2000
- Accession Number
- ADA385431
Entities
People
- Richard A. Fishel
Organizations
- Thomas Jefferson University