Suppression of Vascular Growth in Breast Cancer
Abstract
Thrombospondin-1 is an extracellular matrix protein that has been shown to modulate the response of endothelial cells to growth factors. Specifically the protein suppresses endothelial cell proliferation, migration and angiogenesis in vivo. This grant allowed us to ascertain the significance of thrombospondin for the suppression of the vasculature in mammary tumors. Utilizing null and TSP-1 overexpressing mice, we determined that the protein plays a major role in the size, architecture, and number of vessels in mammary tumors.
Document Details
- Document Type
- Technical Report
- Publication Date
- Oct 01, 1999
- Accession Number
- ADA385653
Entities
People
- Luisa Iruela-arispe
Organizations
- University of California, Los Angeles