Natural History of Plexiform Neurofibromas in NF1
Abstract
This report marks the completion of the first year of the project Natural History of Plexiform Neurofibromas in NF1'. The goals of the project are to test the utility of volumetric MRI in the measurement of plexiform neurofibromas, to use this approach to develop a body of normative data on the growth of plexiform neurofibromas, and to establish an infrastructure including radiology, statistical analysis, clinical database, tissue bank, and pathology review that will facilitate future clinical trials. This first year was devoted to developing the infrastructure of the project and initiating subject recruitment. Major accomplishments include holding a conference at the Banbury Center at which the protocol was refined, establishing MRI data transfer between the participating centers and the radiology analysis facility at WorldCare, creation of the clinical data entry forms, and establishing the communications between the participating centers and the coordinating center in Boston. Patient recruitment has begun, but has been delayed because of a longer than anticipated time required for the approval by the army IRB of the local informed consents. This process is nearing completion, and it is anticipated that subject recruitment will be complete within an additional six months.
Document Details
- Document Type
- Technical Report
- Publication Date
- Oct 01, 1999
- Accession Number
- ADA385657
Entities
People
- Bruce R. Korf