Androgen and Vitamin D Receptor Gene Polymorphisms and Breast Cancer Risk
Abstract
This project will assess the association between the risk of breast cancer and polymorphisms of the androgen and vitamin D receptor among subjects in a recently- completed population-based case-control study in Sweden. A total of 3879 cases and 3527 controls took part, providing questionnaire data regarding use of exogenous hormones and other life style factors. From this study population, 1800 cases and 1800 controls will be randomly selected for genomic DNA analysis. The collection of blood or tissue specimens for DNA has been funded from other sources; this award is for the measurement of the AR and VDR on 300 cases and 300 controls who never used HRT, and 300 cases and 300 controls who used HRT for 4 years or more. Information on these polymorphisms will be incorporated into the established subject database, and odds ratios summarizing the associations with breast cancer risk will be computed. In the first year of the project, the administrative arrangements for the work were established, and a tracking database for subject recruitment and specimen accrual built. Recruitment into the molecular epidemiology study is proceeding well, and the anticipated laboratory analyses will begin shortly.
Document Details
- Document Type
- Technical Report
- Publication Date
- Oct 01, 1999
- Accession Number
- ADA385662
Entities
People
- John A. Baron
Organizations
- Dartmouth College