High Temperature Superconductor RF Probes for Breast Cancer Research
Abstract
In the third year, we have procured specialized cryo-valves, low-temperature components and Oxford cryostat. All these components are assembled with the HTS coil. The complete HTS probe is under final evaluation. We have concentrated on in vivo NMR spectroscopy and micro-imaging studies of MCF7 wild type and MCF7/ADR drug resistant tumors. A localized NMR spectroscopy technique ISIS (image-selected in vivo spectroscopy) was implemented. Detailed in vivo P-31 spectra were obtained. Many phosphate metabolites are identified and they are similar to the in vitro results. During tumor progression, the phosphocreatine and adenosine triphosphate gradually decrease while the inorganic phosphate increases. The control signals of non-involved muscle show constant intensities. The phosphomonoester and phosphodiester signals are too weak for an accurate measurement. For the microscopic imaging of mouse, it demonstrated many small capillaries. The image resolution of 30 micrometers is accomplished.
Document Details
- Document Type
- Technical Report
- Publication Date
- Oct 01, 1999
- Accession Number
- ADA385675
Entities
People
- Paul C Wang
Organizations
- Howard University