Semiannual Report Biology and Medicine
Abstract
The biomedical program in the Donner Laboratory of the Lawrence Radiation Laboratory traces its beginning to the first biomedical investigations carried out in 1935 with heavy particles and artificially produced radioisotopes from the then newly developed cyclotron. These studies soon indicated to us the importance of this growing field of research in biology and medicine. One of the first persons to recognize this was Mr. William H. Donner who attended a seminar in New Haven where some of the early work was presented. He visited Berkeley and shortly afterwards, in 194O, provided funds for the construction of Donner Laboratory. which was dedicated to "the application of physics. chemistry, and the natural sciences to biology and medicine." This concept of an interdisciplinary approach. originally established as the basic pattern for research carried out in the Laboratory. continues to be our philosophy. In the present issue, the paper by Landaw and Winchell, taken from a Ph. D. Thesis, demonstrates how metabolism of heme and heme enzymes can be traced by monitoring the breath for labeled carbon dioxide. This work has many implications and applications in basic research and in space physiology. The article by Loughman. Winchell, Raju and Lawrence illustrates our continuing interest in the development of new radiation knowledge for potential application in the therapy of human neoplasias. Negative pion beams may have important therapeutic implications. Since it has been shown that there is a significant cytogenetic difference in biological effectiveness at the end of the pi meson's range in tissue, this effect resulting from the ionization caused by the secondaries produced when the pi meson is captured in tissue. Aspects of cellular kinetics of a variety of blood cells are discussed in several papers.
Document Details
- Document Type
- Technical Report
- Publication Date
- Jan 01, 1966
- Accession Number
- ADA385707
Entities
People
- John H. Lawrence
- Tove Neville
Organizations
- University of California