New Classes of Conditional Toxins as Therapeutic Agents Against Breast Cancer
Abstract
During the second year of support by the grant DAMDl7-98-l-8042 (The Idea Grant) we focused on the following projects: 1) Further development of signal-regulated, cleavage-mediated toxins. During this year, we completed the work on the CUP9-mediated, HIV protease-dependent conditional toxins. A paper describing these results is nearly finished, and will be submitted for publication this summer. 2) The effort of the previous two years to construct better portable degrons (degradation signals) that can be used, in particular, for designing of conditional toxins was successful. A paper describing these results was published at the end of 1999 (Suzuki & Varshavsky. Degradation signals in the lysine-asparagine sequence space. EMBO J. 18:6017-6026, 1999). 3) In 1999, we completed the construction of a bivalent inhibitor of the N-end rule pathway, a useful reagent for conditional-toxin projects, and published this new approach (Kwon & Varshavsky. Bivalent inhibitor of the N-end rule pathway. J. Biol. Chem. 274:18135-18139, 1999). 4) Other projects that encompass the subject of this grant are under way. They are briefly described below.
Document Details
- Document Type
- Technical Report
- Publication Date
- Apr 01, 2000
- Accession Number
- ADA385933
Entities
People
- Alexander Varshavsky
Organizations
- California Institute of Technology