Identification of Novel Candidate Tumor Suppressor Genes Using C. elegans as a Model
Abstract
Molecular genetic analysis of the model organism Caenorhabditis elegans was used to identify and study mechanisms of action of negative regulators of tyrosine kinase/RAS mediated signal transduction that are candidate tumor suppressors. A homolog of the proto oncogene cbl, SLI- 1, inhibits Ras activation by the epidermal growth factor receptor homolog LET-23. Three functional domains of SLI-1 have been identified. The ARK-i protein kinase was discovered and shown to inhibit signaling by LET-23. New screens for additional negative regulators have identified at several genes that will be molecularly cloned.
Document Details
- Document Type
- Technical Report
- Publication Date
- Nov 01, 1999
- Accession Number
- ADA386042
Entities
People
- Paul W. Sternberg
Organizations
- California Institute of Technology