Non-Human Primate Model for Performance Effects of Ethanol
Abstract
Twenty adult male rhesus monkeys (M. mulatta) ingested various doses of ethanol mixed in orange-flavored drink (10 to 20% ethanol by volume). After each dose, 4-5 blood samples were analyzed to determine peak blood alcohol level (BAL), so as to estimate a dose-response function for each animal. Then, in different (but balanced) random orders, the animals received ethanol doses estimated to produce BALs of 0.00, 0.08, 0.12, 0.16, and 0.20%. Performance of a well-trained compensatory tracking task, the Primate Equilibrium Platform (PEP) task, was tested for 2 hr, commencing 30 min after the beginning of ethanol ingestion (which was completed in < 15 min). BAL was determined at 30 min intervals before, during, and after PEP testing. The significant and dose-related performance decrements induced by ethanol varied in severity from nearly undetectable at the lowest dose to periods of incapacitation in many subjects at the highest dose.
Document Details
- Document Type
- Technical Report
- Publication Date
- Sep 01, 2000
- Accession Number
- ADA386069
Entities
People
- Dennis W. Blick
- Donald J. Cosgrove
- Frank R. Weathersby Jr.
- Michael R. Murphy
- Stephanie Miller