Identification and Characterization of Proteins Involved in Integrin Signaling

Abstract

The development and function of multicellular animals requires integrin adhesion receptors. Integrin-dependent cell adhesion is regulated, in part, by ligand binding affinity ("activation") changes controlled by cellular signaling cascades. Regulation of integrin affinity is important in cell migration, extracellular matrix assembly and morphogenesis. Integrin activation is energy-dependent, and is mediated by cell type specific signals operating through integrin cytoplasmic domains.

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Document Details

Document Type
Technical Report
Publication Date
Sep 01, 1999
Accession Number
ADA386515

Entities

People

  • Csilla A. Fenczik

Organizations

  • Scripps Research

Tags

Communities of Interest

  • Biomedical

DTIC Thesaurus Topics

  • Adhesion
  • Amino Acids
  • Animals
  • Biomedical Research
  • Carrier Proteins
  • Cell Membrane
  • Cell Membrane Structures
  • Cell Movement
  • Cell Physiological Processes
  • Cells
  • Identification
  • Integrins
  • Laboratory Animals
  • Materials
  • Mutations
  • Proteins
  • Recombinant Dna

Fields of Study

  • Biology
  • Chemistry

Readers

  • Molecular Biology and Genetics