Regulation of Cell Cyclin Dependent Kinase Inhibitors in the Prostate Cell by RRR-Alpha-Tocopheryl Succinate
Abstract
Specific Aims Environmental factors including diet play an important role in the initiation and progression of prostate cancer. Our hypothesis was that vitamin E succinate (VES) inhibits cell cycle progression of prostatic cancer cells and thereby reduces cell proliferation, which may lead to more apoptosis. The aim of the grant was to determine (1) if there is differential regulation of p21 and other cell cyclins in response to VES, and determine if VES will arrest prostate cells at either the G0-01 or G2-M phase of the cell cycle; (2) if VES exposure is associated with increased apoptosis in prostate cells, or is there just cytostasis alone.
Document Details
- Document Type
- Technical Report
- Publication Date
- Jun 01, 2000
- Accession Number
- ADA386638
Entities
Organizations
- Howard University