In Vivo Models of NF-1: The Nervous System and Tumorigenesis
Abstract
The present document summarizes the work of three years in which we have endeavored to better understand the mechanisms that lead to NF1 and the relationship between NFl and the related rasGap gene. The approach was to generate conditional mutations in both the NFl and rasGap genes as a means of combining these two otherwise embryonic lethal mutations to examine their cooperation in the physiology of cells, in disease and in tumor formation. While we succeeded in generating the NF conditional mutation, we failed to generate the rasGap mutation. However the study of conditional mutant mice for NF1 has yielded unexpectedly rewarding data. These mice have demonstrated their utility in teaching us about cancer, astrogliosis and many other features of NFl that are seen in patients. The fruits of the work in the preceding funding period have generated a multiplicity of exciting projects that will be the subject of study in our laboratory and many other laboratories for years to come.
Document Details
- Document Type
- Technical Report
- Publication Date
- Sep 01, 2000
- Accession Number
- ADA386768
Entities
People
- Luis F. Parada
Organizations
- University of Texas Southwestern Medical Center