Secretory Heat Shock Protein - gp96-Ig Chaperoned Her-2/New Vaccines

Abstract

The hypothesis that secreted heat shock protein gp96 will trigger an immune response was tested in a tumor system in experimental animals. It was found that gp96 is able to induce tumor specific CD8 CTL without the help of CD4 cells. The postulated molecular and cellular mechanism involves the following steps: 1) gp96-Ig peptide secretion; 2) Binding to endocytosis receptor on dendritic cells; 3) Dendritic cell activation/maturation, including up-regulated expression of CD8O/86; 4) Uptake of gp96 and routing of peptides to endoplasmic reticulum; 5) loading of trimmed peptides on class I MHC molecules and transport to the cell surface; 6) CD8- pre-CTL activation (independent of CD4 T cell help).

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Document Details

Document Type
Technical Report
Publication Date
Jul 01, 2000
Accession Number
ADA386799

Entities

People

  • Eckhard Podack

Organizations

  • University of Miami

Tags

DTIC Thesaurus Topics

  • Animal Structures
  • Biological Factors
  • Blood
  • Breast Cancer
  • Carcinoma
  • Cell Physiological Processes
  • Cells
  • Chemistry
  • Endoplasmic Reticulum
  • Gene Expression
  • Laboratory Animals
  • Lymphatic System
  • Lymphocytes
  • Molecules
  • Peptides
  • Proteins
  • T Lymphocytes

Fields of Study

  • Biology

Readers

  • Cellular and Molecular Pathways of Apoptosis.
  • Immunology

Technology Areas

  • Biotechnology
  • Biotechnology - Cancer Biotech