FC-Gamma Receptor-Targeted Immunization for Breast Cancer

Abstract

The objective of this research project is to test the hypothesis that immune responses to a cancer antigen that is commonly overexpressed in breast cancer can be selectively enhanced and lead to protection against such tumors. This hypothesis of Fcgamma receptor-targeted immunization is being tested through the construction of conjugates or fusion proteins containing the HER2/neu antigen and an antibody that targets HER2/neu to antigen-presenting cells via Fcgamma receptor IIIA. Appropriate immunoconjugates have been prepared and are undergoing testing in a murine model transgenic for human FcgammaRIII. If the hypothesis is validated in the initial experiments, we will construct recombinant fusion proteins with similar specificities and will determine if the sera of immunized mice possess anti-tumor effects

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Document Details

Document Type
Technical Report
Publication Date
May 01, 2000
Accession Number
ADA386800

Entities

People

  • Louis Weiner

Organizations

  • Fox Chase Cancer Center

Tags

DTIC Thesaurus Topics

  • Animals
  • Antibodies
  • Biomedical Research
  • Breast Cancer
  • Cancer
  • Cells
  • Immunization
  • Laboratory Animals
  • Materials
  • Molecules
  • Neoplasms
  • Proteins
  • Recombinant Dna
  • Recombinant Proteins
  • Standards
  • Surface Plasmon Resonance
  • Surface Plasmons

Fields of Study

  • Biology

Readers

  • Immunology