Development of an Assay for Prostate Cancer Based on Methylation Status of Glutathione S-Transferase-pi
Abstract
Prostate cancer is currently the most commonly diagnosed cancer in American men. Early diagnosis through accurate screening techniques will significantly contribute to the successful management and eventual eradication of this disease. Currently, serum PSA determination remains the cornerstone of prostate cancer screening. However, more accurate screening to better differentiate patients with benign disease from those with prostatic cancer will alleviate the unnecessary surgical procedures with a significant impact on patient morbidity and health care costs. Glutathione-s- transferases (GSTs) are a family of detoxification enzymes which catalyze the conjugation of a wide variety of endogenous and exogenous toxins with glutathione.
Document Details
- Document Type
- Technical Report
- Publication Date
- Mar 01, 2000
- Accession Number
- ADA387638
Entities
People
- Jeffrey S Ross
Organizations
- Albany Medical College