Contrast Enhanced 3D Color Amplitude Imaging of the Breasts
Abstract
In total, 21 patients with 6 cancers and 15 benign lesions have been enrolled in the Optison arm of the study. These numbers were much less than anticipated, due to personnel illness and changes. No data analysis has yet been carried out due to the limited data set available for Optison. A one year no-cost extension with a carryover of the unspent balance was requested and granted to allow completion of the project, including data collection and analyses. The histomorphometry system has been used to analyze vessel distribution and vessel density maps from 14 patients. Contrast enhanced color flow imaging was found to provide some quantitative parameters, which correlated with direct pathologic vascularity assessments such as the iMVD. Specifically, the microvessel area and count for vessels 30 to 39 %m in diameter were most significant. These results indicate that ultrasound imaging with contrast may produce a quantitative measure of the neovascularity within breast tumors. However, the current patient population in the sub-study is very small and further cases are currently being analyzed.
Document Details
- Document Type
- Technical Report
- Publication Date
- Oct 01, 2000
- Accession Number
- ADA387647
Entities
People
- Flemming Forsberg
Organizations
- Thomas Jefferson University