Characterization of the Mechanisms of IGF-I-Mediated Stress-Activated Protein Kinase Activation in Human Breast Cancer Cell MCF-7

Abstract

Cumulative evidence shows that insulin-like growth factor (IGF-I) plays an important role in the mitogenesis of breast cancer cells. IGF-I stimulates cell division by regulating events during the early G1 phase, but little is known about the signal transduction pathways involved in these events. The purposes for this proposal are: 1) what is the role of protein kinase C in the IGF-I-induced SAPK/JNK activation in human breast cancer cells MCF-7.2). what is the relationship between IGF-I-induced SAPK/JNK signaling pathway and cyclic AMP-dependent protein kinase A signaling pathway. Our specific aims in this proposal are 1).

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Document Details

Document Type
Technical Report
Publication Date
Jul 01, 2000
Accession Number
ADA387725

Entities

People

  • Javdutt Vadgama
  • Wei Liu

Organizations

  • Charles R. Drew University of Medicine and Science

Tags

DTIC Thesaurus Topics

  • Acids
  • Amino Acids
  • Antibodies
  • Biomedical Research
  • Breast Cancer
  • Cell Division
  • Cell Line
  • Cell Physiological Processes
  • Cells
  • Gene Expression
  • Growth Factors
  • Inhibitors
  • Laboratory Animals
  • Materials
  • Neoplasms
  • Recombinant Dna
  • Tumor Cell Line

Fields of Study

  • Biology

Readers

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  • Molecular Biology and Genetics