Regulation of the Tumor Suppressor Protein PTEN by Phosphorylation
Abstract
The purpose of the research project of this grant is to study the role of phosphorylation on the regulation of PTEN, a tumor suppressor localized on a chromosome region frequently deleted in various cancers including prostate cancer. Preliminary data presented in the research proposal indicated that PTEN is a phosphoprotein. In this year the major phosphorylation sites of PTEN have been mapped in the C-terminus domain (the tail). It has been demonstrated that the phosphorylation of the PTEN tail regulates its protein stability and its activity. This results made us propose a model in which the PTEN can be found in two different states, in a more inactive but more stable state when is phosphorylated on the tail or in more active but more unstable when is unphosphorylated. In the next year we hope to identify the signaling that results in phosphorylation of the PTEN tail. The tail kinases by regulating PTEN can also be implicated in cancer. As stated on the grant proposal, 17% of prostate tumors have lost PTEN protein, however PTEN may be deregulated in those tumors which still retain PTEN protein. A certain percentage of tumors may have deregulation of PTEN tail kinases.
Document Details
- Document Type
- Technical Report
- Publication Date
- Jul 01, 2000
- Accession Number
- ADA387735
Entities
People
- Francisca Vazquez
Organizations
- Dana–Farber Cancer Institute