C-ERBB-2 Receptor Signaling and Breast Cancer Metastasis
Abstract
In this study, we investigated the structural requirements of erbB2 for erbB2 mediated higher metastatic potential in human breast cancer cells. We found that the kinase domain of erbB2 receptor is required for erbB2 to enhance metastatic potential of human breast cancer cells. The C-terminal tyrosine of erbE2 may also play roles in erbB2 mediated higher metastatic potential of breast cancer cells. We also provided the evidence that HRG/egf can promote the metastatic potential of MDA-MB-435 cell erbB2 transfectants in vivo. In addition, we investigated the signaling mechanism of heregulin enhanced MCF-7 and SKBR-3 cell aggregation. We found that HRG-beta 1-induced PI3-kinase activation is required in HRG enhanced MCF-7 and SKBR-3 breast cancer cell aggregation. Our studies have generated important information about the molecular basis of breast cancer invasion and metastasis. Ultimately we may use the information to develop new prognostic indicators and novel therapies for breast cancer metastasis.
Document Details
- Document Type
- Technical Report
- Publication Date
- Aug 01, 2000
- Accession Number
- ADA387767
Entities
People
- Ming Tan
Organizations
- The University of Texas MD Anderson Cancer Center