Development of Bioavailability Adjustment Factors: A Feasibility Study
Abstract
The primary purpose of this effort is to investigate the feasibility of developing and using bioavailability adjustment factors to modify intake assumptions used in risk assessments on a site-specific basis. A survey was conducted for the Air Force Institute for Environment, Safety and Occupational Health Risk Analysis (AFIERA) to determine the policies of each state regarding the use of site-specific bioavailability data in conducting human health risk assessments. State regulatory agencies from each of the fifty states were contacted via electronic mail and/or telephone to request information on guidance documents used to determine the applicability of bioavailability considerations in risk assessment, the previous use of site-specific bioavailability adjustments, and the likelihood of state acceptability of bioavailability considerations in future risk assessments. Of the responses received, a majority of the states have no current written guidance on the use of bioavailability adjustments in risk assessment, nor any plans to generate guidance. While the majority of states indicated a willingness to consider bioavailability adjustments in future risk assessments, there is a lack of precedent in most states. We conclude that, while the use of bioavailability adjustment is a powerful tool in risk assessment, initial attempts to gain acceptance of the methodology by state regulators would require a significant effort due to a lack of accepted guidance.
Document Details
- Document Type
- Technical Report
- Publication Date
- Dec 01, 2000
- Accession Number
- ADA387935
Entities
People
- Elizabeth A. Maull
- Jeff Duffy
- Steve J. Rembish